皮肤失生症和皮肤植物病:尚未探索的联系
Aparajita Ghosh1, Saumya Panda2
1From the Department of Dermatology, K.P.C Medical College and Hospital, Kolkata, West Bengal, India.
Indian journal of dermatology
|December 15, 2023
概括
皮肤失生症,皮肤微生物组的不平衡,与皮肤菌感染有关,如 tinea. 虽然研究表明微生物组发生了变化,但需要更多的研究来证实因果关系.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 皮肤拥有复杂的微生物群,对屏障功能和免疫调节至关重要.
- 皮肤失调,这种微生物组的不平衡,越来越多地与炎症性皮肤疾病有关.
- 在皮肤菌感染中,特别是慢性和耐药形式中,失生症的作用值得研究.
研究的目的:
- 通过使用独立于培养的方法,审查分析皮肤微生物群在皮肤菌感染中的研究.
- 评估各种形式的 tinea 感染中皮肤失生症的证据.
主要方法:
- 在PubMed和谷歌学者数据库的系统文献搜索.
- 包括使用测序方法分析皮肤微生物组合的研究.
- 专注于比较感染个体与健康对照个体中的微生物模式的研究.
主要成果:
- 四项研究满足了纳入标准,重点研究的是头炎,乳头炎和脚.
- 所有纳入的研究都表明患者和对照人群之间的微生物物种多样性和丰度存在显著差异.
- 对于其他 tinea 形式 (例如, tinea cruris, corporis) 没有发现数据.
结论:
- 现有研究表明,改变的皮肤微生物组 (dysbiosis) 和皮肤植物病之间存在关联.
- 目前的证据不足以确定因果关系;变化可能是感染的结果.
- 需要对各种类型和地理区域进行进一步的纵向研究.
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