相关实验视频

Updated: Sep 30, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

纤维细胞生长因子13-中介调节中等脊髓神经元刺激性和可卡因自我管理

Nolan M Dvorak¹, Jessica Di Re¹, Tileena E S Vasquez¹

¹Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United States.

Frontiers in neuroscience

|December 15, 2023

概括

纤维细胞生长因子13 (FGF13) 可能会防止可卡因使用障碍 (CUD). 降低FGF13在大脑中的作用.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
遗传学是一个遗传学.

背景情况:

可卡因使用障碍 (CUD) 是一个重要的公共卫生问题,治疗选择有限.
环境的隔离增加了可卡因的自我管理和核 accumbens 贝中等状神经元 (NAcSh MSN) 刺激性.
确定CUD的新型治疗点至关重要.

研究的目的:

调查可卡因自我管理和NAcSh MSN兴奋性的基础分子机制.
在CUD的背景下,确定纤维细胞生长因子13 (FGF13) 在NAcSh中的作用.

主要方法:

从不同环境条件下从老鼠获得NAcSh的二次转录组分析.
在NAcSh中,在体内对FGF13进行基因沉默.
对NAcSh MSNs的电生理记录.
对可卡因需求弹性的评估.

主要成果:

自给可卡因改变了NAcSh中的FGF13mRNA水平,敏感 (隔离) 鼠的水平较低.
在NAcSh中抑制FGF13通过增强电压接的Na+ (Na_v) 通道活动,增加了MSN刺激性.
FGF13敲击降低了可卡因需求弹性,表明对可卡因的敏感性增加.

结论:

在NAcSh中,FGF13在可卡因自我管理方面起着保护作用.
FGF13调节NAcSh MSN刺激性和Na_v通道活动.
FGF13代表了治疗可卡因使用障碍的潜在药理目标.

关键词:

可卡因使用障碍是可卡因使用障碍.纤维细胞生长因子13 中等的刺状神经元.原子核是的外.电压关闭的Na+通道.

更多相关视频

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Using Optogenetics to Reverse Neuroplasticity and Inhibit Cocaine Seeking in Rats

Published on: October 5, 2021

相关概念视频

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...