左心室应变曲线的基于特征的聚类,用于一般人群中心血管风险分层
Evangelos Ntalianis1, Nicholas Cauwenberghs1, František Sabovčik1
1Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Frontiers in cardiovascular medicine
|December 15, 2023
概括
机器学习在一般人群中确定了四个不同的左心室 (LV) 菌株现象组. 这些由详细的LV菌株曲线得出的现象组预测了超出峰值LV菌株测量的心血管事件风险.
科学领域:
- 心血管成像和诊断服务
- 机器学习在医疗保健中的应用
- 对心血管疾病的预测分析.
背景情况:
- 亚临床心血管疾病的识别对于风险分层至关重要.
- 峰值左心室 (LV) 缩应变是一种已知的预后因素.
- 对于完整的心脏周期LV菌株概况存在有限的分析.
研究的目的:
- 将无监督的机器学习应用于LV应变曲线时间序列特征.
- 为了识别与心血管不良事件相关的不同的LV菌株现象组.
- 评估这些现象组在一般人群中的预后价值.
主要方法:
- 长度研究1185个社区居民的基线心声谱.
- 斯混合模型 (GMM) 应用于LV应变曲线特征 (斜坡,峰值应变,扩散).
- 外部验证使用额外的队列 (n=545) 和特征重要性的SHAP值.
主要成果:
- 确定了四个不同的LV菌株现象组.
- 现象组3和4显著增加了心血管和心脏不良事件的风险.
- 时间应变特征 (心缩和早期心缩倾斜) 比峰值LV应变更具影响力.
结论:
- 在LV菌株曲线上无监督的机器学习可以提取临床意义上的现象组.
- 这些现象组提供了超出传统峰值LV菌株的附加预后信息.
- 这种方法提高了一般人群中心血管事件的风险分层.
相关概念视频
Imaging Studies for Cardiovascular System I:Echocardiography
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Imaging Studies for Cardiovascular System IV: CMRI
Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...


