宿主基因对不同种族群体传染病的影响
Lisa Naidoo1, Thilona Arumugam1, Veron Ramsuran1,2
1School of Laboratory Medicine and Medical Sciences College of Health Sciences University of KwaZulu-Natal Durban 4041 South Africa.
Advanced genetics (Hoboken, N.J.)
|December 15, 2023
概括
主体遗传学显著影响了对疟疾,结核病 (TB),艾滋病毒和COVID-19等传染病的易感性,特别是在非洲. 了解这些遗传变异可以导致针对高疾病负担的个性化治疗.
科学领域:
- 遗传学和传染病的研究
- 人口遗传学 人口遗传学
- 宿主-病原体相互作用
背景情况:
- 全球传染病如疟疾,结核病,艾滋病毒和COVID-19不成比例地影响非洲,造成大量死亡.
- 个体易感性和疾病进展受到遗传学,环境和病原体因素的影响.
- 主体遗传学是各种传染病中疾病易感性的关键决定因素.
研究的目的:
- 分析不同族群的宿主基因和与艾滋病毒,结核病,疟疾和COVID-19相关的遗传变异.
- 审查宿主-病原体相互作用的差异,特别是高加索和非洲人群之间的差异.
- 为了确定非洲人口中普遍存在的基因多态性,从而增加疾病风险或保护.
主要方法:
- 对宿主基因和与主要传染病相关的遗传变异的文献综述.
- 对跨种族群体的宿主-病原体相互作用进行比较分析,重点关注非洲和高加索的后裔.
- 检查与疾病易感性和进展相关的基因多态性.
主要成果:
- 几种宿主基因和多态性通常与多种传染病有关.
- 民族之间存在宿主-病原体相互作用和遗传倾向的显著差异.
- 在非洲人群中普遍存在的特定基因多态可能会提供保护或增加这些疾病的风险.
结论:
- 宿主遗传在感染疟疾,结核病,艾滋病毒和COVID-19等传染病的易感性方面发挥着至关重要的作用.
- 了解特定种族的遗传变异对于解决传染病负担至关重要.
- 本综述为开发针对非洲人群量身定制的个性化治疗提供了洞察力.
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