一次性先天性玻璃眼:一种 iridotrabeculodysgenesis?
Ramanjit Sihota1, Karthikeyan Mahalingam, Ashok Kumar Maurya
1Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian journal of ophthalmology
|December 15, 2023
概括
前段光学连贯性断层扫描 (ASOCT) 在初级先天性玻璃眼 (PCG) 患者中揭示了前面的虹膜接和虹膜低成形. 这些发现可以作为疾病严重程度和预后的生物标志物.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 遗传学 是一个
- 生物标志物 生物标志物
背景情况:
- 初级先天性玻璃眼 (PCG) 是一种严重的发育障碍,影响眼睛的前部.
- 了解PCG中的结构异常对于预测疾病进展和治疗结果至关重要.
研究的目的:
- 分析PCG患者的前腔和角度异常,使用前段光学连贯断层扫描 (ASOCT).
- 确定评估PCG严重程度和预后的潜在生物标志物.
主要方法:
- 一项涉及PCG患者 (年龄大于4) 和年龄匹配对照的横截面观察研究.
- 使用ASOCT (CASIA-2) 分析了前段异常.
- 前侧虹膜膜粘附和虹膜插入使用虹膜膜膜膜接触指数 (ITC) 量化.
主要成果:
- 与对照人群相比,PCG眼睛显著增加了前面虹膜膜粘附,改变了角膜和前腔体积,并减少了轨道膜网状结构.
- 前侧虹膜膜粘附与中部角膜厚度和虹膜厚度正相关.
- 虹膜低成形,以较少的折叠和缺少领膜/瞳孔形为特征,在PCG眼中显著不同.
结论:
- 在PCG眼中,ASOCT揭示了可变的前面虹膜接,异常的角度组织和虹膜低成形.
- 这些特征与手术前的杯盘比率相关,可以作为PCG严重程度和预后的临床生物标志物.
- 显然,PCG是更广泛的前部分段失生谱的一部分,而不仅仅是孤立的轨道管失生.
相关概念视频
Glaucoma: Overview
584
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
584
Angle Closure Glaucoma: Treatment
514
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
514
Open Angle Glaucoma: Treatment
455
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
455
Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K


