在初级开角青光眼中,抗青光眼药物治疗的眼球表面变化与以前没有接受过治疗的患者相比
Krati Srivastava1, Kavita R Bhatnagar, Jyoti Shakrawal
1Department of Ophthalmology, AIIMS, Jodhpur, Rajasthan, India.
Indian journal of ophthalmology
|December 15, 2023
概括
使用抗青光眼药物 (AGMs) 的青光眼患者比未接受过治疗的患者更容易出现干眼疾病 (DED). AGM会恶化眼睛表面疾病,突出显示需要在绿眼的护理中进行DED评估.
科学领域:
- 眼科医生 眼科 眼科
- 眼睛表面疾病 眼睛表面疾病
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
- 眼睛表面疾病 (OSD) 在青光眼患者中很常见,可能会因治疗而恶化.
- 抗光眼药物 (AGM) 对眼睛表面的影响需要进一步调查.
研究的目的:
- 为了比较AGM的POAG患者与未经治疗的POAG患者的眼球表面疾病的患病率和严重程度.
- 为了评估两个组在12个月内眼睛表面参数的纵向变化.
主要方法:
- 一项前性队列研究,涉及60名POAG患者 (120只眼睛),分为以前未接受过治疗的 (I组) 和接受过AGM治疗的 (II组) 组.
- 包括眼皮表面疾病指数 (OSDI) 问卷,撕裂破裂时间 (TBUT),希尔默测试,角膜敏感性,AS-OCT和染色等全面的格洛科马检查.
- 评估是在基线和1,3,6和12个月后期进行的.
主要成果:
- 与AGM治疗的患者 (II组) 相比,在治疗前的患者 (I组) 显著表现出更好的TBUT,希尔默测试结果,撕裂半径高度 (TMH) 和撕裂半径深度 (TMD) 在基线.
- 利萨明绿色和色孟加拉色彩在II组中显示出更严重的眼睛表面损伤.
- 两组在随访期间都显示出OSD恶化,但I组始终保持着更好的眼睛表面参数.
结论:
- 与以前没有接受过治疗的患者相比,接受AGM治疗的玻璃眼患者受到干眼疾病 (DED) 的影响要大得多.
- 在整个随访期间,在TBUT,希尔默测试,染色和AS-OCT参数之间观察到群体之间的统计学上显著差异.
- 建议对使用局部AGM的青光眼患者进行DED/OSD的常规评估和管理,特别是那些服用多种或频繁服用药物的患者.
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