在免疫功能低下的儿科患者中管理急性COVID-19
Federico Mercolini1, Nicoletta Abram1, Simone Cesaro2
1Pediatric Oncology and Hematology "Lalla Seràgnoli", IRCCS, Azienda Ospedaliero-Universitaria di Bologna institution, Bologna, Italy.
Expert review of clinical immunology
|December 15, 2023
概括
在免疫功能受损的儿童中管理2019年新冠肺炎疾病 (COVID-19) 已经通过抗病毒药物和疫苗等新疗法得到改善. 早期干预是减少这些脆弱儿科患者的严重程度和住院治疗的关键.
科学领域:
- 儿童传染病 儿童传染病
- 免疫性受损的主体
- COVID-19 治疗方法 治疗方法
背景情况:
- SARS-CoV-2 感染对免疫力低下的儿童构成重大威胁.
- 儿科COVID-19的管理策略在整个流行病期间都在发展.
研究的目的:
- 审查儿童COVID-19的治疗策略,重点是免疫功能低下的患者.
- 讨论成人治疗方案适应儿科患者群体的情况.
主要方法:
- 对儿科COVID-19治疗选择的文献综述.
- 基于感染严重程度的治疗有效性的分析.
- 讨论预防和早期干预策略.
主要成果:
- 治疗方案包括抗尖峰单克隆抗体,抗病毒药物,抗炎药物和免疫调节剂.
- 疫苗接种和预防传播对于降低感染风险至关重要.
- 在高风险免疫受损儿童的早期干预可以减少病毒泄露和严重的后果.
结论:
- 儿童COVID-19治疗反映了成年人的治疗方案,但需要仔细对患者的严重程度进行校准.
- 及时治疗对于免疫功能受损的儿科患者至关重要,以预防严重疾病,住院和死亡.
- 需要进一步研究延迟治疗在血液瘤儿科患者的长期结果.
相关概念视频
Immunodeficiency Diseases
947
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
947
Transmission-based Precautions II: Airborne and Protective Environment
1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K
Acute Respiratory Failure-V
142
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
142
Pneumonia IV: Management
333
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
333
Pneumonia V: Nursing management and Prevention
2.1K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.1K
Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244


