沉默长时间下降的内部扩大自身脊髓神经元改善后肢踏步后伤脊髓损伤
Courtney T Shepard1,2,3, Brandon L Brown1,2,3, Morgan A Van Rijswijck3,4
1Interdisciplinary Program in Translational Neuroscience, School of Interdisciplinary and Graduate Studies, University of Louisville, Louisville, United States.
eLife
|December 15, 2023
概括
沉默长时间下降的自身脊髓神经元 (LDPNs) 破坏了完整的老鼠的四肢交替,但改善了脊髓损伤 (SCI) 后的恢复. 这表明LDPN和LAPN协调四肢运动,而LDPN可能会阻碍SCI后的腰部电路功能.
科学领域:
- 神经科学是一个神经科学.
- 脊髓损伤研究 脊髓损伤研究
- 机车运动 机车运动
背景情况:
- 脊柱运动电路依赖于由自身脊柱神经元相互连接的节律发生器来控制步态.
- 长长的上升性脊髓神经元 (LAPN) 对于四肢间协调至关重要,它们的沉默可以改善脊髓损伤 (SCI) 后的恢复.
研究的目的:
- 调查长下降自身脊髓神经元 (LDPNs) 在运动控制和SCI恢复中的作用.
- 在肢体间协调的背景下,将LDPN与LAPN的功能进行比较.
主要方法:
- 成年大鼠的LDPN有条件沉默.
- 在完整和SCI大鼠模型中评估运动机能.
主要成果:
- 沉默LDPN在完整的老鼠中破坏了四肢交替.
- 沉默LDPNs在胸部伤SCI后显著改善了运动器官功能.
- LAPN和LDPN似乎在宫和腰部中心之间的时间信息交换中具有相似的作用.
结论:
- LDPNs在协调四肢交替方面发挥着重要作用.
- 扰乱LDPN功能可增强SCI后的发动机恢复,这表明它们可能会阻碍伤害后的腰部电路功能.
- 无论是LAPN还是LDPN都对正常行走至关重要,但它们的破坏可以通过允许独立的腰部电路功能来帮助恢复.
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