相关实验视频

Updated: Jul 8, 2025

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

亚临床甲状腺功能低下症和抗甲状腺过氧化酶抗体在初级开角绿内障:一个病例对照研究

Suma Unnikrishnan¹, V P Anilakumari², Ferzana Mohammed¹

¹Department of Ophthalmology, Government Medical College, Kozhikode, Kerala, India.

Indian journal of ophthalmology

|December 15, 2023

概括

这项研究发现,原发性开角玻璃眼 (POAG) 和亚临床甲状腺功能低下症之间存在显著的关联. 患有POAG的患者更有可能患有亚临床甲状腺功能低下症,这表明这两种情况之间存在潜在联系.

科学领域:

眼科医生眼科眼科
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

主要开角玻璃眼 (POAG) 是全球不可逆转失明的主要原因.
亚临床甲状腺功能低下症,以高甲状腺刺激激素 (TSH) 与正常的自由甲状腺素 (T4) 和三甲状腺素 (T3) 水平为特征,是一种常见的内分泌疾病.
自身免疫性甲状腺疾病和玻璃眼之间潜在的联系是正在进行的研究领域.

研究的目的:

为了研究亚临床甲状腺功能低下症和初级开角玻璃眼 (POAG) 之间的关联.
评估抗甲状腺过氧化酶 (抗TPO) 抗体在POAG患者中的作用.

主要方法:

对63名POAG患者和63名年龄和性别匹配的对照进行了病例对照研究.
血液样本分析了TSH,T3,T4和抗TPO抗体水平.
统计分析包括曼·惠特尼U测试,奇方测试和几率比率计算与95%的置信区间.

主要成果:

在POAG患者中,亚临床甲状腺功能低下症被诊断为20.6%,对照组为4.8% (P < 0.01).
与对照组相比,患有POAG的患者患亚临床甲状腺功能低下症的几率增加了5.2倍 (95%CI1.7-22).
抗TPO抗体阳性在POAG组 (22.2%) 比对照组 (14.3%) 高,但这种差异在统计学上并不显著 (P = 0.25).

结论:

这项研究表明,亚临床甲状腺功能低下症和POAG之间存在显著的关联.
需要进一步的研究来阐明这些条件之间的因果关系.

更多相关视频

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

相关概念视频

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...