在新血管玻璃眼中与同步的静脉内贝瓦西祖马布进行带切除术
1Glaucoma Services, L. V. Prasad Eye Institute, MTC Campus, Bhubaneswar, Odisha, India.
Indian journal of ophthalmology
|December 15, 2023
概括
同时使用静脉内贝瓦西祖马布 (IVB) 与管切除术和米托菌素-C (MMC) 治疗新血管性玻璃眼 (NVG) 是有效的. 这种综合方法可显著降低眼内压力 (IOP),并减少了手术后需要服用青光眼药物的需要.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 血管生物学 血管生物学
背景情况:
- 新血管性玻璃眼 (NVG) 由于眼内压力升高 (IOP) 和潜在的视力丧失,构成了重大挑战.
- 目前NVG的治疗策略通常涉及管理IOP和潜在的视网膜缺血症.
研究的目的:
- 评估为NVG结合内贝瓦西祖马布 (IVB) 注射与管切除术和线粒激素-C (MMC) 的临床疗效.
- 为了比较并发IVB与轨道切除术/MMC的结果与连续IVB,其次是轨道切除术/MMC的结果.
主要方法:
- 一项回顾性医院研究包括40名NVG患者,分为两组:并发IVB与轨道切除术/MMC (组1) 和顺序IVB,其次是轨道切除术/MMC (组2).
- 主要结局是手术后6个月需要服用内压降低药物.
- 使用逐步多变量回归来确定药物需要的预后因素.
主要成果:
- 与顺序组 (组2) 相比,并发组 (组1) 在6个月内显示出明显较低的IOP (P=0.05).
- 与2组 (11眼睛) 相比,第一组 (3眼睛) 的患者 postoperatively 需要服用抗白内障药物的患者较少.
- 术前IVB注射超过3次和复发的玻璃体出血被确定为需要抗白内障药物的显著预测因素.
结论:
- 同时的静脉内贝瓦西祖马布 (IVB) 与管切除和线粒激素-C (MMC) 是一种可行且有效的治疗新血管玻璃眼 (NVG) 与耐火性高内血压.
- 这种综合方法解决了高的IOP和视网膜缺血症,有可能提高复杂NVG病例的手术成功率.
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