合成和激活pH敏感的金属有机框架Sr(BDC) ∞用于口服药物输送
Andrey Vodyashkin1,2, Antonina Sergorodceva1, Parfait Kezimana1
1RUDN University, 117198, Moscow, Russia.
Dalton transactions (Cambridge, England : 2003)
|December 15, 2023
概括
本研究提出了对二甲甲酸金属有机框架 (Sr(BDC) MOFs) 的改进激活方法,提高了它们的药物递送能力. 激活的MOF显示出低毒性和潜在的安全和有效的多克索鲁比辛输送.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
背景情况:
- 金属有机框架 (MOF) 越来越多地用于生物医学应用.
- 高效的MOF激活对于优化其特性至关重要,特别是在药物输送方面.
- 石甲 (Sr(BDC)) MOF 是一个有前途的材料类.
研究的目的:
- 开发一种用于Sr(BDC) MOFs的新制备方法.
- 建立一种替代的,有效的激活方法,从Sr(BDC) MOF中去除残留溶剂 (DMF).
- 评估激活对Sr(BDC) MOF特性及其适用于药物输送的影响.
主要方法:
- 使用XRD,FTIR,TGA和SEM进行Sr(BDC) MOF的合成和表征.
- 不同激活方法的比较分析,包括乙醇处理.
- 使用多克索鲁比作为模型药物的MOF吸附特性评估.
- 试验室中细胞毒性和亡测定以评估生物安全性.
主要成果:
- 成功合成和表征了Sr(BDC) MOFs.
- 证明乙醇处理有效地去除DMF,改善MOF表面积和孔隙结构.
- 激活的Sr(BDC) MOFs显示了多克索鲁比辛吸附的改善.
- 在测试度中,MOFs表现出较低的细胞毒性和最小的亡诱导.
结论:
- 开发的激活方法对于优化Sr(BDC) MOF性能至关重要.
- 乙醇激活的Sr(BDC) MOF是药物输送应用的有希望,安全和有效的平台.
- 对生物医学应用的Sr(BDC) MOF进行进一步的研究是有必要的.
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