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在微生物群中检测横向基因转移:通过先进的比较分析来识别移动体内的共同共享基因的创新管道

Jana Schwarzerova^1,2, Michal Zeman³, Vladimir Babak³

¹Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology , Brno, Czech Republic.

Microbiology spectrum

|December 15, 2023

概括

横向基因转移 (HGT) 推动了细菌的进化,使得它们能够适应. 这项研究确定了农场动物肠道细菌中的抗生素耐药性基因,突出了农业抗生素使用带来的公共卫生风险.

科学领域:

微生物学和进化生物学
基因组学和生物信息学
公共卫生和兽医公共卫生和兽医.

背景情况:

水平基因转移 (HGT) 是细菌基因组的一个重要的进化机制.
抗生素耐药性基因 (ARG) 通过HGT传播,特别是在农业实践中,这引起了公众健康的担忧.
农场动物的食用肠道微生物群作为ARG的储存库.

研究的目的:

在和猪便样本中识别已知和新动员基因,包括ARG.
调查HGT在农业环境中抵抗基因传播中的作用.
开发和应用一种用于基因识别和网络分析的创新管道.

主要方法:

利用一种新的生物信息管道来识别从元基因组数据中调动的基因.
应用网络分析以可视化基因关系和传播模式.
分析了来自和猪农业环境的便样本.

主要成果:

成功识别了一系列已知和以前未被表征的调动基因.
描述了农场动物肠道微生物群中ARG的HGT潜力.
网络分析提供了对基因调动和传播途径的见解.

结论:

农场动物的肠道微生物群是可调动基因的关键储存库,包括ARG.
在农业环境中,HGT在传播抗生素耐药性方面发挥着至关重要的作用.
开发的管道和网络分析是研究基因动态和公共卫生影响的有效工具.

关键词:

动物微生物群是动物的微生物群.基因组的演化基因组的演化我们的肠道微生物群.横向基因转移是指水平基因转移.移动的遗传元素是移动的.移动ome是一个移动ome.抗性基因是抵抗性的基因.

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