通过肺组织炎症和损伤增强抗菌药物透率
Johannes Geilen1, Matthias Kainz1, Bernhard Zapletal1
1Division of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, Department of Anesthesia, General Intensive Care, and Pain Management.
肺部炎症和损伤增强了抗微生物药物的透,增加了受影响组织中的度. 这表明目前的剂量可能足以治疗重症患者的肺炎.
科学领域:
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
背景情况:
- 肺炎是危急病患被直管的常见并发症.
- 肺组织中适当的抗微生物药物度对于有效治疗和预防耐药性至关重要.
- 肺炎和损伤对抗菌素透的影响尚不清楚.
研究的目的:
- 为了比较肺组织和支气管支气管洗 (BAL) 液体度的ceftaroline fosamil和linezolid. 为了比较肺组织和支气管支气管洗 (BAL) 液体度的ceftaroline fosamil和linezolid.
- 评估是否需要调整剂量,以确保在受伤的肺组织中抗菌剂度足够.
- 调查急性肺损伤对抗微生物药物透在猪中的影响.
主要方法:
- 在猪中诱导单边急性肺损伤.
- 塞法托林 (Ceftaroline) 福萨米尔和莱因佐利德是静脉注射的.
- 药物度在肺组织 (微透析),血液和BAL液中被测量了8小时.
主要成果:
- 在炎症/受伤的肺组织中,与未炎症的组织相比,抗菌素度显著更高.
- 塞法托林 (Ceftaroline fosamil) 和莱因佐利德 (linezolid) 显示组织透率提高,导致超过最小抑制度的时间更长.
- 两种药物都能很好地透到BAL液体中,受伤肺和未受伤肺之间没有显著差异.
结论:
- 早期的肺组织炎症和损伤增强了ceftaroline fosamil和linezolid的透.
- 这种增强的透导致长时间超过最小抑制度.
- 肺部炎症可能会在损伤的急性阶段改善对感染的肺组织的抗菌药物输送.
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