乳腺癌放射治疗后长达12年的肺功能和肺纤维化
Jarle Karlsen1, Torgrim Tandstad1, Sigurd Steinshamn2
1Cancer Clinic, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
International journal of radiation oncology, biology, physics
|December 15, 2023
概括
乳腺癌的治疗方法,如化疗和放射治疗,可以长期影响肺功能. 肺功能测试 (PFTs) 的早期下降预测了以后的问题,但严重的呼吸障碍并不常见.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 辐射疗法 辐射疗法
背景情况:
- 乳腺癌 (BC) 治疗,包括放射治疗 (RT),可能导致肺毒性.
- 在BC治疗后对肺功能的长期证据有限.
研究的目的:
- 为了评估长期的肺功能,辐射纤维化 (RF) 和患者报告的呼吸障碍,在BC治疗后长达12年.
- 评估不同BC治疗方式对肺部结局的影响.
主要方法:
- 包括250名BC患者接受了术后RT.
- 评估肺功能测试 (PFTs),高分辨率计算机断层扫描,临床检查和呼吸障碍在RT之前和之后长达12年.
主要成果:
- 肺功能 (VC,FEV1,FVC) 在RT后早期下降,并保持在低水平,除了DLCO,长期改善.
- 化疗和局部区域RT显著影响了PFTs.
- 早期的PFT下降预测了晚期的PFT下降 (P < .05).
- 91%的人有轻微的长期RF;严重的呼吸障碍是罕见的,与RF或PFT下降无关.
结论:
- 化疗和局部区域性RT对PFTs有持久的影响,治疗后长达12年.
- 早期的RT后PFT减少是长期PFT下降的预测因素.
- 长期PFT下降与辐射纤维化或患者报告的呼吸障碍无关.
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