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Updated: Jul 8, 2025

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具有负自发曲线的脂质降低了癌症药物帕克利塔塞尔在脂质体中的溶解度

Victoria Steffes1,2, Scott MacDonald3, John Crowe3

  • 1Materials Department, University of California, Santa Barbara, CA, 93106, USA.

The European physical journal. E, Soft matter
|December 15, 2023
PubMed
概括

这项研究发现,脂质1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 和甘单酸盐 (GMO) 降低了帕克利塔塞尔 (PTX) 在脂质体中的可溶性. 这些脂质不适合开发有效的PTX药物载体.

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