对SARS-CoV-2感染的微质炎症反应:综合性审查
1Department of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal, 700121, India. rdrajen422@gmail.com.
Cellular and molecular neurobiology
|December 15, 2023
概括
微质细胞被SARS-CoV-2激活会导致神经炎症和认知问题. 针对这种反应可以治疗COVID-19相关的大脑功能障碍和精神疾病.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 由SARS-CoV-2引起的COVID-19主要影响呼吸系统,但也影响包括大脑在内的多个器官.
- 在COVID-19患者中观察到神经精神症状和认知缺陷,其潜在机制需要进一步阐明.
- 微质细胞,大脑的常驻免疫细胞,与SARS-CoV-2感染的神经系统相关.
研究的目的:
- 审查微质在SARS-CoV-2感染中的作用.
- 探索将微质激活与神经炎症和心理行为变化的机制.
- 为开发治疗策略提供信息,以管理COVID-19幸存者的神经炎症.
主要方法:
- 文献综述侧重于微质对SARS-CoV-2的反应.
- 对细胞因子风暴,氧化应激和细胞相互作用的分析.
- 检查神经炎症的潜在治疗点.
主要成果:
- 微质原始化导致SARS-CoV-2相互作用时的过度激活,导致"细胞因子风暴".
- 微结质症释放炎症媒介 (IL-1β,IFN-γ,IL-6),反应性氧/物种 (ROS/RNS) 和升高的CCL11,促进认知功能障碍,MDD和精神疾病.
- 感染期间的微-CD8+ T 细胞相互作用可能会导致神经元细胞死亡.
结论:
- 微质激活是SARS-CoV-2诱导的神经炎症和相关的神经/精神症状的关键因素.
- 了解细胞因子介导的交叉通话对于维持大脑的炎症平衡至关重要.
- 准微质通路为抗击COVID-19后的神经炎症和认知障碍提供了潜在的治疗途径.
更多相关视频
10:40Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
Published on: October 27, 2019
32.2K
09:35Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
9.4K
相关概念视频
01:30Inflammatory Response I: Vascular and Cellular
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
01:24Smallpox
Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
01:29Coronavirus
Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
01:25Acute Inflammation III: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...