与年龄相关的发生率和逆侧乳腺癌的峰值发生率
Hakyoung Kim1,2, Tae In Yoon3, Seonok Kim4
1Division of Breast Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
JAMA network open
|December 15, 2023
概括
年轻的乳腺癌患者 (≤35岁) 面临着明显更高的患有逆侧乳腺癌 (CBC) 的风险. 患有HR-/ERBB2+亚型的年轻患者表现出更早的CBC风险峰值.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 临床研究 临床研究
背景情况:
- 年轻的乳腺癌患者表现出明显的流行病学特征.
- 年轻患者患有逆侧乳腺癌 (CBC) 的风险较高.
研究的目的:
- 为了确定CBC的发病率和峰值发生率与初级乳腺癌 (PBC) 手术时的年龄相关.
- 根据年龄和原发性瘤亚型分析CBC风险.
主要方法:
- 一项对韩国16,251名患有单边非转移性乳腺癌的女性患者的队列研究 (1999-2013).
- 患者被分为年轻人 (≤35岁) 和老年人 (>35岁) 两类.
- 分析包括CBC的累积发病率和危险率,按激素受体 (HR) 和ERBB2状态分层.
主要成果:
- 年轻患者的10年累积发病率 (7.1%对2.9%) 和CBC的风险 (HR,2.10) 显着更高.
- 根据亚型,CBC风险时间有所不同;HR-/ERBB2+亚型显示年轻患者 (1.7岁vs4.8岁) 的峰值风险较早.
- 三重阴性亚型风险在10年左右达到顶峰,而HR+/ERBB2-风险持续增加.
结论:
- 35岁或更年轻的乳腺癌患者患有CBC的风险增加.
- 患有HR-/ERBB2+乳腺癌的年轻患者可能在初始诊断后更早地发生CBC.
- 结果可以为治疗决策提供信息,包括对侧预防性乳房切除术.
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