高流量鼻氧流速对呼吸暂停患者气体交换的影响:一项随机对照试验
C Lyons1, J McElwain1, O Young2
1Department of Anaesthesia, Galway University Hospitals, Galway, Ireland.
Anaesthesia
|December 15, 2023
概括
高流量鼻腔氧气在呼吸暂停期间不会显著改变二氧化碳的积累. 然而,它确实改善了氧气水平,并在接受麻醉的患者中延长了脱的时间.
科学领域:
- 麻醉学 麻醉学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 高流量鼻氧 (HFNO) 用于麻醉期间的氧化前和无呼吸氧化.
- 它在呼吸暂停期间对二氧化碳排放的影响并未得到充分量化.
- 气体交换的最佳HFNO流速仍然是未知的.
研究的目的:
- 调查不同HFNO流速对呼吸暂停期间二氧化碳排放的影响.
- 为了确定最佳的HFNO流速,以维持呼吸暂停期间的氧化.
主要方法:
- 114名患者接受了HFNO以50L/分钟的速度进行先氧化.
- 在呼吸暂停期间,患者被随机分配到接受0,70或120升/分钟的HFNO.
- 在4分钟的呼吸暂停后,测量了动脉血液气体和脱度到SpO2 92%的时间.
主要成果:
- 两组之间没有观察到二氧化碳积累率 (PaCO2增加) 的显著差异.
- 与0L/min组相比,在70L/min和120L/min HFNO组中实现了更高的PaO2水平.
- 与对照组相比,HFNO组 (70和120L/分钟) 的脱时间比92%更长.
结论:
- 在呼吸暂停期间,HFNO不会增强二氧化碳的排放.
- 70L/分钟和120L/分钟的HFNO改善了氧化,并在麻醉期间延长了安全的呼吸暂停时间.
- 可能需要进一步的研究来优化HFNO设置的无呼吸氧化.
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