在接受治疗的固体癌症患者中,对三剂抗SARS-CoV-2 mRNA疫苗的抗体反应
Davide Dalu1, Maciej Tarkowski2, Lorenzo Ruggieri1
1Department of Medical Oncology, Luigi Sacco University Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.
International journal of cancer
|December 15, 2023
概括
接受抗癌治疗的固体癌症患者在第三剂mRNA疫苗接种后表现出改善的抗体反应. 异种疫苗接种方案 (混合疫苗类型) 在提高这一脆弱人群的抗体水平方面似乎更有效.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 固体癌症患者面临SARS-CoV-2感染和严重结果的风险增加.
- 抗癌治疗可以损害癌症患者的疫苗诱导抗体反应.
研究的目的:
- 在接受抗癌治疗的患者中,评估对第三剂mRNA疫苗的抗体反应.
- 为了比较对初级两剂疫苗接种周期的反应.
- 探索异种疫苗方案的有效性.
主要方法:
- 追溯性,观察性,产生假设的队列研究.
- 包括99名接受各种抗癌疗法 (生物,化疗) 的患者.
- 在第三剂mRNA疫苗接种后评估抗体反应.
主要成果:
- 第三剂后血清转化率显著增加,特别是在最初没有反应的人群中.
- 不同类型的疫苗类型方案 (例如,mRNA-1273接着tozinameran,或者反之亦然) 产生了更高的抗体水平.
- 重复的mRNA疫苗剂量可能会增强癌症患者的抗体反应.
结论:
- 重复的mRNA疫苗剂量显示出在固体癌症患者中改善抗体反应的潜力.
- 在这个人群中,三剂异质疫苗接种似乎更有效.
- 需要进一步的统计研究来验证这些发现.
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