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Updated: Jul 8, 2025

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甲氨酸腺转移酶α1的sumoylation促进了与酒精相关的肝病中的线粒体功能障碍

Andrea Floris1, Swati Chandla1, Youngyi Lim2

  • 1Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Hepatology (Baltimore, Md.)
|December 15, 2023
PubMed
概括

在lysine 48 (K48) 中的甲氨基基转移酶α1 (MATα1) 的SUMOylation通过促进与PIN1的相互作用来驱动与酒精相关的肝病 (ALD). 阻止这种SUMOylation可以防止ALD的进展和肝损伤.

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