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Updated: Jul 8, 2025

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在二氧化原酶的催化循环中,甲酸通过减少Fe (III) 来重新编程表观基因组和表转录基因组

Weizhi He1, Xiaotong Yin1, Chu Xu1

  • 1Cancer Institute, Fudan university Shanghai Cancer Center, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Shanghai Medical College of Fudan University, Shanghai 200032, China.

ACS chemical biology
|December 15, 2023
PubMed
概括

亚酸 (ASC) 作为二氧化原酶的辅因子,通过将Fe (III) 降低为Fe (II) 来再生不活跃的酶. 这一过程通过删除mRNAm6A甲基化来重新编程表转录组,揭示了ASC在酶催化中的关键作用.

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