亚急性轻度创伤性脑损伤中的动态相锁状态和个性:一项探索性研究
Harm J van der Horn1,2, Myrthe E de Koning3, Koen Visser1
1Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
PloS one
|December 15, 2023
概括
情绪不稳定是一种人格特征,与轻度创伤性脑损伤 (mTBI) 后的大脑连接和持续症状的改变有关. 特定的大脑网络状态可能会影响mTBI患者的症状严重程度,特别是那些情绪不稳定的患者.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 不适应性人格特征,特别是神经病,与轻度创伤性脑损伤 (mTBI) 后的较差结果有关.
- 了解连接个性和mTBI恢复的神经机制对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究个性和mTBI后持久症状之间的关系的神经支柱.
- 探索动态功能网络连接 (dFNC) 和扩散MRI (dMRI) 在mTBI结果中的作用.
主要方法:
- 在27名mTBI患者和21名健康对照 (HC) 中利用休息状态fMRI (rs-fMRI) 和dMRI.
- 在受伤后六个月评估个性维度 (五大) 和症状严重程度.
- 采用主要组件分析 (PCA) 用于人格因素和领先的自身向量动态分析 (LEiDA) 用于dFNC,以及基于dMRI的路径空间统计.
主要成果:
- 在mTBI患者和HC患者之间,dFNC总体阶段锁定状态没有显著差异.
- 在mTBI患者中,分数异构性下降的趋势,特别是在白质道中,如和体.
- 一个特定的dFNC状态,涉及执行/saliency和默认模式网络,与较低的症状严重程度有关,这种影响在情绪不稳定的患者中更为明显.
结论:
- 初步证据表明,在mTBI后长期症状的发展中,个性 (情绪不稳定) 和dFNC之间存在联系.
- 特定的动态大脑网络状态可能会调解个性对mTBI恢复的影响.
- 在这项研究中,dMRI发现与动态相锁状态没有直接相关.
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