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早期人类肺部免疫细胞的发展及其在上皮细胞命运中的作用

Josephine L Barnes1, Masahiro Yoshida1,2, Peng He3,4

  • 1UCL Respiratory, Division of Medicine, University College London, London, UK.

Science immunology
|December 15, 2023
PubMed
概括

发育中的人类肺部拥有多种免疫细胞,包括先天性淋巴细胞和淋巴细胞,这些细胞可能会影响上皮细胞的发育. 来自髓状细胞的介质素-1β (IL-1β) 似乎引导了上皮细胞的分化.

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Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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