母亲的不良童年经历 (ACE) 和后代在出生时印记了基因DMR甲基化
Adriana C Vidal1, David W Sosnowski2, Joddy Marchesoni1
1Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Epigenetics
|December 15, 2023
概括
母亲的不良童年经历 (ACE),财务压力和歧视与新生儿DNA甲基化模式的改变有关. 印制基因中的这些表观遗传变化可能会影响跨世代的长期健康.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 健康和疾病的发育起源 (DOHaD)
- 基因组印记是一种基因组印记.
背景情况:
- 不良的童年经历 (ACE) 与不良的健康结果有关.
- 表观遗传修饰,如DNA甲基化,对环境暴露很敏感.
- 印制基因在胎儿发育中起着至关重要的作用,易受表观遗传失调的影响.
研究的目的:
- 调查母亲ACE,财务压力和歧视与新生儿印记基因区域的DNA甲基化之间的关联.
- 检查这些母体暴露和它们对后代表观遗传学的影响之间的潜在相互作用.
主要方法:
- 对232名孕妇进行前性队列研究.
- 关于ACE,财务压力和歧视的自我报告数据.
- 激光测序用于评估印制基因 (例如,PEG10/SGCE,NNAT,IGF2,H19,PLAGL1,PEG3,MEG3-IG,DLK1/MEG3) 中的八个差异甲基化区域 (DMR) 的DNA甲基化.
- 用多变量线性回归模型进行分析.
主要成果:
- 财务压力与非西班牙裔白人新生儿中MEG3-IG的高甲基化有关.
- 歧视与西班牙裔新生儿IGF2和NNAT的高甲基化和非西班牙裔黑人新生儿PEG3的低甲基化有关.
- 孕产妇ACE与歧视相互作用,以影响PLAGL1,H19和SGCE/PEG10 DMRs的甲基化,尽管这些在校正后没有达到统计学意义.
结论:
- 孕妇在怀孕期间接触ACE,歧视和经济压力与新生儿印记基因区域的异常DNA甲基化有关.
- 这些发现突出了潜在的表观遗传机制,将生命早期的逆境与代际健康联系起来.
- 需要进一步的研究来确认这些表观遗传变化的功能意义和长期影响.
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