医用大麻用于临终关怀的疼痛管理,作为计划阿片类药物的补充方法:单臂研究
Theodore Zanker1,2,3, Joseph Sacco1,2,4,5, James Prota2,6
1Department of Medicine, The Connecticut Hospice, Branford, CT, USA.
The American journal of hospice & palliative care
|December 15, 2023
概括
将医用大麻与阿片类药物结合起来,显著减少了宿舍患者的疼痛. 这种方法可能会降低阿片类药物的剂量和毒性,为终身疼痛管理提供更安全的替代方案.
科学领域:
- 息治疗和疼痛管理
- 综合性瘤学 综合性瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿片类药物治疗对于临终关怀疼痛管理至关重要,但往往受到不良影响的限制.
- 医用大麻可能提供一种补充方法,以减轻阿片类药物的副作用,同时保持疼痛缓解.
研究的目的:
- 调查医用大麻和阿片类药物疗法的联合对宿舍住院患者疼痛缓解的影响.
- 评估阿片类药物剂量,食欲,呼吸功能,幸福感,恶心和不良事件的变化.
主要方法:
- 一项单臂研究涉及66名接受计划性阿片类药物治疗的成年宿舍住院患者.
- 参与者接受了标准化的口服医用大麻 (40毫克CBD/1.5毫克THC或80毫克CBD/3毫克THC).
- 纵向混合效应回归模型分析了996个治疗日的治疗效应.
主要成果:
- 观察到疼痛强度的统计学上显著的纵向减少 (P = .0029).
- 观察到一种非显著的趋势,即较低的阿片类药物剂量.
- 轻微,可逆的不良事件发生在4.5%的患者中;没有报告严重的不良事件.
结论:
- 结合医用大麻和阿片类药物治疗在宿舍患者中显示出显著的疼痛缓解.
- 这种组合可能会降低阿片类药物的剂量和毒性,呈现出潜在的更安全的疼痛管理选择.
- 对于终身护理机构,需要在更大规模的受控试验中进行进一步的调查.
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