压力与多种长期疾病之间的关联:一个队列研究
Hilda Hounkpatin1, Glenn Simpson1, Miriam Santer1
1Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, University of Southampton, United Kingdom.
Journal of psychosomatic research
|December 15, 2023
概括
高水平的皮质醇,一种压力生物标志物,与老年人发展和积累多种长期疾病 (MLTC) 的风险增加有关. 这一发现强调了压力作为减少MLTC风险的潜在目标.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 生物医学科学 生物医学科学
背景情况:
- 压力是已知的慢性健康状况的预测因素.
- 头发皮质醇是长期应激暴露的可靠生物标志物.
- 多重长期疾病 (MLTC) 在老年人群中构成重大健康负担.
研究的目的:
- 调查头发皮质醇水平与MLTC的发生率和积累之间的关联.
- 为了确定皮质醇是否预测新的长期疾病的发展.
- 探索压力生物标志物与多种慢性疾病的进展之间的关系.
主要方法:
- 利用了来自英国老龄化纵向研究的4295名老年人 (年龄≥50岁) 的数据.
- 测量了头发皮质醇作为慢性压力的生物标志物.
- 采用Cox的比例危险模型来评估基线皮质醇和6年时间内的MLTC积累之间的联系.
主要成果:
- 较高的皮质醇水平显著与累积MLTC的风险增加有关.
- 在调整了社会人口统计学因素和健康行为之后,这种关联仍然很重要.
- 没有MLTC的个人在基线显示,患有新疾病的风险更高,头发皮质醇升高.
结论:
- 这项研究提供了新的证据,将慢性压力,如发皮质醇,与MLTC的发展和积累联系起来.
- 头发皮质醇可能作为一种可修改的风险因素,可以针对减轻MLTC.
- 需要进一步的研究来阐明连接压力和MLTC积累的确切机制.
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