下体的功能连接与步态结有关,与多巴反应有关
Daniel H Lench1, Jade D Doolittle1, Viswanathan Ramakrishnan2
1Department of Neurology, Medical University of South Carlina, Charleston, SC, USA.
Parkinsonism & related disorders
|December 15, 2023
概括
在帕金森病 (PD) 中,步态结 (FOG) 与大脑连接在体下核 (STN) 的改变有关. 与对多巴无反应的FOG相比,对多巴有反应的FOG显示出明显的STN连接模式.
科学领域:
- 神经科学是一个神经科学.
- 运动障碍 运动障碍
- 功能神经成像 功能神经成像
背景情况:
- 步态结 (FOG) 是帕金森病 (PD) 的重要和致残的症状.
- 亚thalamic核 (STN) 在运动控制中起着至关重要的作用,是深度大脑刺激 (DBS) 的常见目标.
- 了解与FOG对多巴胺药物反应相关的STN电路对于治疗优化至关重要.
研究的目的:
- 为了研究STN在帕金森病 (PD) 患者的功能连接,有或没有对多巴反应的步态结 (FOG).
- 确定与FOG中对多巴胺作用药物的反应相关的特定STN脑电路.
主要方法:
- 在55名PD参与者 (38名有FOG,17名没有FOG) 中,比较了STN的静止状态BOLD功能连接性.
- 将FOG参与者再分为对多巴反应 (n=22) 和对多巴不反应 (n=16) 的组.
- 利用部分相关性来评估FOG多巴反应和STN连接之间的关系,控制年龄,疾病持续时间和药物剂量.
主要成果:
- 对多巴反应的FOG表现出更强的右STN连接与小脑运动区域和/皮层.
- 左STN与皮皮层的连接性在对多巴反应的FOG中更高,而与后中心环的连接性在对多巴反应不好的FOG中更大.
- 连接强度与l-dopa诱导的FOG改善相关 (UPDRS第14项),但不是整体运动得分 (UPDRS第三部分).
结论:
- 不对多巴反应的FOG与STN和参与运动和感官处理的区域之间的改变的BOLD功能连接有关.
- 这些发现表明,有效的FOG治疗可能需要参与运动和感官大脑网络.
- 这项研究支持了解FOG病理生理学和指导治疗策略的框架.
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