在临床阶段IVB胃癌中成功进行转换手术的治疗策略
Yudai Hojo1, Yoshinori Ishida1, Toshihiko Tomita2
1Department of Gastroenterological Surgery, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
概括
转化手术 (CS) 在晚期胃癌 (GC) 患者中是成功的. 持续的化疗改善了临床阶段IVBGC的治疗结果和生存率,无论治疗线路如何.
科学领域:
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
- 医学瘤学 医学瘤学
背景情况:
- 最近的化疗进展使得临床阶段 (cStage) IVB胃癌 (GC) 的转化手术 (CS) 成为可能.
- 评估CS成功率和优化治疗对于管理高级GC至关重要.
研究的目的:
- 评估在cStage IVB GC患者中转化手术的实际成功率.
- 确定最佳的手术前化疗策略,以获得成功的CS和改善生存率.
主要方法:
- 从2017年1月至2022年6月接受化疗的166名IVB期GC患者的回顾性分析.
- 在手术前至少6个月的化疗后,对M0疾病进行了CS,不包括可切除的肝转移.
主要成果:
- 在125名符合条件的患者中,23人接受了CS,产生了18.4%的转化率和91.3%的R0切除.
- 手术前化学疗法的中位数为8.5个月 (8个周期).
- 癌症神经系统患者的中位生存时间比单独化疗 (16 个月;P < .0001) 显著长 (56.7 个月).
结论:
- 一致的化疗策略有助于在cStage IVB GC中成功的CS.
- 成功的CS显著改善了预后,无论使用哪种化疗线.
- 这种方法为更多的晚期GC患者提供了改善的生存率.
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