在生物治疗后患有结性脊髓炎的患者中T细胞受体谱的动力学
Wei-Chih Liu1, Che-Mai Chang1, Yanfeng Zhang2
1Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
International immunopharmacology
|December 15, 2023
概括
T细胞受体 (TCR) 谱系的变化与接受生物药物的结性脊髓炎 (AS) 患者的治疗成功相关. 增加TCR曲目多样性和特定的克隆类型预测了积极的治疗结果,有助于预后评估.
科学领域:
- 免疫学 免疫学 免疫学
- 自免疫性疾病 自免疫性疾病
- 类风湿病学 类风湿病学
背景情况:
- 脊髓炎 (AS) 是一种慢性炎症性自身免疫性疾病,涉及T细胞反应.
- 在AS中观察到改变的T细胞受体 (TCR) 谱系概况,与扩展的疾病相关的TCR克隆型相关.
- 生物制剂对TCR剧目的影响及其与治疗结果的关联仍然不清楚.
研究的目的:
- 研究生物疗法如何影响AS患者的TCR曲谱特征.
- 确定TCR曲目动态是否与AS治疗结果有关.
- 探索TCR谱系概况,疾病活性和炎症标志物之间的关系.
主要方法:
- 在生物治疗前后从AS患者收集的临床样本.
- 在患者样本上进行TCR谱系测序 (TCRα和TCRβ).
- 分析了TCR曲目特征,疾病活性和细胞因子水平 (例如IL-23) 之间的关联.
主要成果:
- 良好的响应者显示TCR曲目多样性增加,并增加了TCR克隆类型的比例.
- 发现TCR谱系多样性和互白素-23 (IL-23) 水平之间存在正相关性.
- 网络分析在治疗后的良好响应者中确定了具有共同CDR3动机的主导的合同AS相关的TCR克隆类型.
结论:
- 改变TCR谱系与生物治疗AS患者的治疗结果有显著的联系.
- 在AS中,TCR曲目状态和动态可以作为生物治疗的预后指标.
- 了解TCR曲目变化,可以了解AS的治疗反应机制.
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