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非洲毒素B1和病毒的联合致病性:对invitro和invivo研究的微型系统性综述

Mehdi Ahmadi¹, Ramin Shahbahrami², Fatemeh Khajeh³

¹Student Research Committee, (Department and Faculty of Nutrition Sciences and Food Technology), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Acta histochemica

|December 15, 2023

概括

结合HBV,EBV和流感等病毒的阿弗拉托克辛B1 (AFB1) 可能会加剧疾病. 这篇评论强调AFB1是病毒致癌的辅因子,敦促进一步研究这些复杂的相互作用.

科学领域:

毒理学毒理学毒理学
病毒学病毒学
致癌的发生是致癌的产生.

背景情况:

非洲毒素B1 (AFB1) 和诸如乙型肝炎病毒 (HBV),爱斯坦-巴尔病毒 (EBV) 和流感病毒等病毒对病原发生的联合作用尚未完全理解.
研究这些共同暴露的分子机制和潜在的协同效应对于了解疾病进展至关重要.

研究的目的:

进行对体外和体外研究的系统审查,检查亚毒素和各种病毒的联合致病性.
综合目前关于AFB1和病毒感染之间的相互作用的证据.

主要方法:

按照PRISMA指南进行的系统审查.
用于研究资格评估的PECO (人口,暴露,比较,结果) 标准.
对21项符合条件的研究进行了定性分析.

主要成果:

14项研究重点关注AFB1和HBV,4项研究关注AFB1和流感A病毒 (SIV),2项研究关注AFB1和EBV,1项研究关注AFB1和C型肝炎病毒 (HCV).
发现AFB1可以增强EBV和流感病毒的病原性.
AFB1作为HBV和EBV介导的致癌的辅因子,而HBV和HCV也诱导了AFB1的致癌.

结论:

有限的证据表明,AFB1增强了EBV和流感病毒的发病因子,并作为病毒致癌的辅因子.
HBV和HCV也可能诱导AFB1的致癌.
由于有限的数据和不一致的发现,进一步的研究,特别是关于HBV和SIV与AFB1的相互作用,是必不可少的.

关键词:

非洲毒素 (Aflatoxins) 是一种毒素.在体外 (in-vitro) 进行.在生物体内.系统性审查系统性审查病毒性疾病是一种病毒性疾病.病毒感染是一种病毒感染.

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Viral Recombination

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