实验室获得的感染和病原体在2000年至2021年期间在全球范围内逃逸:一个范围审查
Stuart D Blacksell1, Sandhya Dhawan2, Marina Kusumoto2
1Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Nuffield Department of Medicine Research Building, University of Oxford, Oxford, UK.
The Lancet. Microbe
|December 15, 2023
概括
实验室获得的感染 (LAI) 和意外的病原体逃逸 (APELS) 构成风险. 对2000-2021年公共数据的审查发现了309个LAI和16个APELS,强调需要更好的全球报告和事件分析.
科学领域:
- 生物安全和生物安全.
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 实验室获得的感染 (LAI) 和意外的病原体逃逸 (APELS) 构成了重大的公共卫生问题.
- 目前用于病原体研究的风险管理策略面临挑战,原因是风险感知和容忍不一致.
研究的目的:
- 在2000年至2021年期间对公共可用的LAI和APELS报告进行范围审查.
- 识别与LAI和APELS相关的病原体和情况.
- 为改善生物安全管理框架提供信息.
主要方法:
- 对同行评审文献和媒体报道进行范围审查.
- 从2000年到2021年收集有关LAI和APELS事件的数据.
- 分析病原体类型,事件数量和死亡人数.
主要成果:
- 确定了309个涉及51种病原体的LAI,其中沙门氏菌肠道血清型Typhimurium是最常见的.
- 八个死亡是由于LAI引起的,这些病原体包括Neisseria meningitidis和Yersinia pestis.
- 报告了16个APELS,涉及病原体,如Bacillus anthracis和脊髓灰质炎病毒.
结论:
- 根源原因分析和对LAI和APELS的彻底调查对于防止未来事件至关重要.
- 依赖公共数据引入了偏见,强调了需要正式的全球报告系统.
- 改进数据收集和分析对于全面了解LAI和APELS风险至关重要.
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