塞斯特林2通过AMPK激活和ROS抑制抑制RANKL诱导的骨质细胞形成

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A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation

Published on: March 15, 2018

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Kabsun Kim1, Jung Ha Kim2, Inyoung Kim1

  • 1Department of Pharmacology, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea.

Free radical biology & medicine
|December 15, 2023
PubMed
概括

塞斯特林2 (Sesn2) 抑制骨质细胞形成,这是骨质损失的一个关键过程. 抗生素阿齐思罗米 (Azm) 增强了Sesn2,通过减少骨质再吸收,为骨质疏松症提供了潜在的治疗方法.

关键词:
通过AMP激活的蛋白质激酶.亚齐思罗密辛是一种亚齐思罗密辛.核因子与红色素衍生因子2相关的因子2相关的核因子.骨质结晶体 骨质结晶体 是一个有反应性氧物种的反应性氧物种.这就是Sestrin2的原因.

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