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从Hypericum wilsonii中发现具有生物活性的多环聚乙烯酸黄醇与阿达曼/homoadamantane骨

Bo Tao¹, Yongqi Li¹, Zhengyi Shi¹

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

|December 15, 2023

概括

在Hypericum wilsonii中发现了九种新的多环多烯酸酸. 一种化合物通过抑制氧化的产生表现出抗炎作用,另一种化合物通过抑制T淋巴细胞增殖表现出免疫抑制作用.

科学领域:

自然产品化学自然产品化学
药理学药理学是指药理学的学科.
药用化学医学化学

背景情况:

众所周知,Hypericum物种是生物活性化合物的来源.
多环多乙烯酸氨基醇 (PPAP) 具有多种生物活性.
对Hypericum wilsonii的化学和生物研究正在进行中.

研究的目的:

从Hypericum wilsonii中分离和描述新的化合物.
评估隔离化合物的抗炎和免疫抑制潜力.

主要方法:

使用HRESIMS,NMR和X射线晶体学进行隔离和结构阐明.
生物测试包括LPS刺激RAW264.7细胞中的氧化抑制.
评估T淋巴细胞增殖和亚种群变化.

主要成果:

确定了9种新的PPAP,库米尔醇A-I,以及6种已知的类似物.
化合物13 (hyperacmosin G) 显示出显著的氧化抑制 (IC50 = 4.35 μM) 和抗炎作用.
化合物5显示显著抑制T淋巴细胞增殖 (IC50 = 4.80μM) 和免疫抑制活性.

结论:

该研究确定了来自Hypericum wilsonii的新型阿达曼/homoadamantane含有的PPAP.
化合物13显示出潜在的抗炎性质.
化合物5显示出显著的免疫抑制活性,表明治疗潜力.

关键词:

抗炎性活动抗炎性活动这种植物是Hypericaceae.这种植物名为Hypericum wilsonii N. 罗布森.具有免疫抑制活性的药物.聚环多乙烯酸化乙烯基氨基醇 (Polycyclic polyprenylated acylphloroglucinols) 是一种多环多乙烯酸的化合物.

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