3D打印的囊外用于个性化剂量循环氨酸装载的SNEDDS
Mohammed S Algahtani1, Abdul Aleem Mohammed1, Javed Ahmad1
1Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia.
International journal of pharmaceutics
|December 15, 2023
概括
这项研究提出了一种新的方法,将自纳米乳化药物递送系统 (SNEDDS) 与3D打印相结合,用于个性化的环素 (CsA) 剂量. 这种方法提高了CsA的溶解性,并使量身定制的输送,改善患者的结果.
科学领域:
- 药品制造 药品制造 药品制造
- 药物输送系统 药物输送系统
- 生物医学工程 生物医学工程
背景情况:
- 环素 (CsA) 是一种重要的免疫抑制剂,具有较差的溶解性和狭窄的治疗指数,导致患者的结果和不良反应变化.
- 在CsA治疗中的挑战包括由于受试者之间的变异性和可溶性问题而导致的移植排斥和毒性.
- 需要个性化医疗方法来优化CSA的疗效和安全性.
研究的目的:
- 开发一种结合SNEDDS的新型药物输送系统,以提高CSA的溶解性.
- 利用3D打印技术,为个性化,按需的剂量形式创建装有CSA的SNEDDS.
- 评估开发的配方的物理化学特性和体外药物释放.
主要方法:
- 通过使用液体SNEDDS配方与特定的油 (卡普洛伊尔90,八酸) 和Smix (克雷莫El,PEG 400) 阶段,提高了CsA的溶解性.
- 优化的液体SNEDDS使用PEG 6000进行了固化,并装入3D打印的囊外中.
- 描述包括FTIR,DSC和SEM/EDX;进行了体外药物释放研究.
主要成果:
- 用CSA加载的SNEDDS配方已成功准备和表征.
- 在体外释放研究表明,CsA在60分钟内完全释放,遵循Korsmeyer-Peppas动力学.
- 药物释放动力学是独立于外开口的大小和装载配方的数量.
结论:
- 开发了一种新,简单,直截了当的方法,用于个性化剂量输送CSA载荷的SNEDDS.
- 结合SNEDDS和3D打印,提供了一种有前途的方法来克服CsA的可溶性限制和可变性.
- 这项技术有可能在免疫抑制疗法中提高治疗疗效和患者安全.
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