肝血管变化与叙利亚仓鼠和人类的Opisthorchis猫科动物感染相关

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Anna V Kovner¹, Yaroslav K Kapushchak¹, Oxana Zaparina¹

¹Institute of Cytology and Genetics (ICG), Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Ak. Lavrentiev Ave., Novosibirsk 630090, Russia.

|December 15, 2023

概括

猫科动物Opisthorchis的肝通过促进新的血管生长 (新血管生成) 和粉样质沉积,导致肝纤维化. 这项研究将增加的新血管生成与慢性光症中的纤维化严重程度联系在一起.

科学领域:

寄生虫学的寄生虫学
肝病学肝病学是一种肝病学.
病变的发生和发病.

背景情况:

猫虫 (Opisthorchis felineus) 是一种通过食物传播的动物性肝炎,导致肝胆道疾病和纤维化.
在opisthorchiasis病原体中驱动纤维化并发症的机制正在积极研究中.
病理性血管生成与通过炎症细胞招募和矩阵调节的纤维化进展有关.

研究的目的:

为了评估动物模型和患有慢性光症的人类患者的肝脏组织中的新血管生成和粉样质沉积物.
评估新血管生成和肝纤维化严重程度之间的相关性.
为了研究血管新生在O.猫科动物感染引起的肝纤维化中的作用.

主要方法:

对感染者和未感染者的肝脏组织进行组织病理学检查.
使用CD34染色对新形成的血管进行新血管生成的评估.
在肝脏组织中对粉样蛋白沉积物的分析.
回归分析以将新血管生成与纤维化严重程度相关联.

主要成果:

在患有慢性 opisthorchiasis 的个体的肝脏中观察到新形成的血管 (新血管生成) 和粉样沉积物显著增加.
新血管新生和粉样沉积物在O. felineus感染的Mesocricetus auratus模型中首次被证明.
新形成的CD34+血管与肝纤维化严重程度有正相关性.

结论:

新血管生成和粉样沉积是慢性Opisthorchis猫科动物感染的重要病理特征.
血管新生在与O. felineus感染相关的肝纤维化进展中发挥着潜在的作用.
这些发现提供了对与opisthorchiasis相关的肝损伤病源的洞察.

关键词:

氨基粉症是什么氨基粉症是什么血管新生的产生.CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD31 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 纤维化纤维化纤维化梅索克里塞图斯奥拉图斯,人类这种动物叫Opisthorchis felineus.

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