[身体质量指数与类风湿性关节炎的临床特征之间的相关性分析]
Jing Feng Zhang1, Yin Ji Jin1, Hui Wei1
1Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.
概括
超重和肥胖的类风湿性关节炎 (RA) 患者表现出较低的疾病活性,但高血压,糖尿病和高脂血症的比例较高. 肥胖与心血管风险因素的增加有关,但不一定是RA中的心血管疾病.
科学领域:
- 风湿病学和免疫学
- 临床流行病学临床流行病学
- 肥胖问题研究研究
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响关节.
- 身体质量指数 (BMI) 对RA临床特征和并发症的影响尚未完全理解.
- 超重和肥胖是普遍存在的疾病,已知与各种健康问题有关.
研究的目的:
- 为了研究超重和肥胖的RA患者的临床特征.
- 确定BMI与疾病活动,关节外表现和RA的并发症之间的关系.
主要方法:
- 追溯分析了481名RA患者的人口统计数据,关节外表现,并发症和疾病活性.
- 根据BMI,根据世卫组织的标准将患者分为正常,超重和肥胖的群体.
- 统计分析包括t测试,威尔科克森等级总和测试,奇平方测试和后勤回归.
主要成果:
- 超重和肥胖的RA患者 (29.3%) 的高血压,糖尿病,高脂血症和脂肪肝的发病率显著增加.
- 这些群体也患有较高的骨关节炎,但骨质疏松症和贫血的发病率较低.
- 疾病活动标志物 (CRP,ESR,VAS,DAS-28) 在超重和肥胖的RA患者中较低.
结论:
- 超重和肥胖与RA患者高血压,糖尿病和高脂血症的风险增加有关.
- 在超重和肥胖个体中,RA疾病的活性似乎较低.
- 在这个队列中,超重和肥胖与心血管和脑血管疾病无关.
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