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相关概念视频

Stem Cell Culture01:17

Stem Cell Culture

5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
23.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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相关实验视频

Updated: Jul 8, 2025

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
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High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

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通过新兴的生物医学策略来设计干细胞.

Jinglin Wang1, Xiaoxuan Zhang2, Hanxu Chen2

  • 1Department of Vascular Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China; Division of Hepatobiliary Surgery and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

Science bulletin
|December 15, 2023
PubMed
概括
此摘要是机器生成的。

工程干细胞增强了难治性疾病的治疗潜力. 本综述详细介绍了干细胞工程的进展,应用以及未来临床翻译前景.

关键词:
生物材料是一种生物材料.生物打印是一种生物打印技术.遗传修饰是一种基因改造.微流体学 微流体学器官在芯片上的器官干细胞是一种干细胞.

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科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 细胞生物学 细胞生物学

背景情况:

  • 干细胞疗法对难以治愈的疾病有前景,在临床试验中已证实安全性.
  • 目前的干细胞疗法在治疗效益和临床研究数据稳定性方面存在局限性.
  • 工程方法对于优化干细胞的有效性和开发下一代疗法至关重要.

研究的目的:

  • 提供工程干细胞的全面分析.
  • 审查干细胞生产和工程策略的最新进展.
  • 讨论工程干细胞的临床应用,挑战和未来前景.

主要方法:

  • 关于干细胞工程的最新科学文献的综述.
  • 分析干细胞生产的进展,包括诱导多能干细胞 (iPSC),胚胎干细胞 (ESC),介质干细胞 (MSC) 和造血干细胞 (HSC).
  • 检查分子生物学和生物材料领域的工程策略.

主要成果:

  • 详细概述工程干细胞策略及其在生物医学研究中的应用.
  • 探索临床应用和潜在的未来发展.
  • 识别工程干细胞目前的障碍和未来的方向.

结论:

  • 工程干细胞在克服传统干细胞治疗的局限性方面取得了重大进展.
  • 工程技术的进一步研究和开发对于成功的临床翻译至关重要.
  • 工程干细胞在治疗各种疾病和推进生物医学应用方面具有巨大的前景.