对于周围假肢关节感染的持续局部抗生素 perfusion 的治疗经验
Yoshiaki Miyake1, Toru Takagi1
1Department of Orthopaedic Surgery, Japanese Red Cross Okayama Hospital, 2-1-1 Aoe, Kita-ku, Okayama, 700-8607, Japan.
概括
持续局部抗生素输液 (CLAP) 有效治疗周围假肢关节感染 (PJI). 这种方法在所有接受治疗的患者中成功解决了感染,没有复发或并发症.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 生物医学工程 生物医学工程
背景情况:
- 周围假肢关节感染 (PJI) 需要高度的抗生素来消除生物膜.
- 在PJI中通过静脉注射达到治疗性抗生素水平具有挑战性.
- 持续局部抗生素 perfusion (CLAP) 提供了一种方法来增加局部抗生素度.
研究的目的:
- 评估CLAP在治疗PJI中的有效性和安全性.
- 报告用CLAP治疗的PJI患者的临床结果.
主要方法:
- 用CLAP治疗的八名PJI患者的回顾性分析.
- 分析的参数包括PJI分类,手术程序,CLAP持续时间和感染分辨率.
- 通过静脉给药的抗生素和C反应蛋白 (CRP) 水平进行了监测.
主要成果:
- 所有八名患者 (平均年龄为73.5岁) 均成功解决了感染.
- 平均CLAP持续时间为8.5天,平均静脉输入抗生素的时间为22.4天.
- 没有观察到CLAP的复发或系统性副作用.
结论:
- CLAP是PJI的一个有价值的治疗选择.
- 在所有患者中,CLAP的联合使用导致了成功的感染解决.
- 在这个PJI队列中,CLAP表现出了有利的安全概况.
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