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Updated: Jul 8, 2025

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PAX3-FOXO1使用其激活域来招募CBP/P300并塑造RNA Pol2集群分布

Yaw Asante1, Katharina Benischke2, Issra Osman3

  • 1Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.

Nature communications
|December 15, 2023
PubMed
概括

在PAX3-FOXO1 (P3F) 中的一个关键的氨酸招募CBP/p300,这对于膜性狂宫肌肉瘤 (aRMS) 中的瘤基因转录至关重要. 破坏这种相互作用会阻止癌细胞的生长,并揭示出新的治疗点.

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