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大型B细胞淋巴瘤在CD19导向的CAR T细胞治疗后复发的治疗选择
Samantha El Warrak1, Mohamed A Kharfan-Dabaja2, Madiha Iqbal2
1Department of Internal Medicine, University of Connecticut, Farmington, CT, USA.
Bone marrow transplantation
|December 15, 2023
概括
化学抗原受体T细胞疗法 (CAR T) 为大型B细胞淋巴瘤 (LBCL) 提供了新的希望,但对没有反应的患者仍然存在挑战. 本综述探讨了在LBCL中CART失败后优化结果的策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 化学抗原受体T细胞疗法 (CAR T) 已经改变了大型B细胞淋巴瘤 (LBCL) 治疗.
- 显著的一小部分LBCL患者无法实现对CAR T治疗的持久反应.
研究的目的:
- 审查和分析治疗后复发或耐药LBCL患者的管理策略.
- 评估各种治疗方式在CAR T后环境中的疗效.
主要方法:
- 对LBCL后CART衰竭治疗方法的现有数据的文献综述.
- 对单克隆抗体,抗体与药物合物,双特异性抗体和全原造血细胞移植研究的分析.
主要成果:
- 针对CD19的疗法在CAR T后的环境中显示出有限的疗效.
- 双特异性抗体提供了一个替代方案,但缺乏CAR T后的长期随访数据.
- 异质造血细胞移植显示出有效性,但前提是在手术前实现完全缓解.
结论:
- 在CART衰竭后治疗LBCL是一个重大的治疗挑战.
- 需要采用多方面的治疗方法来优化这些患者的治疗结果.
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