在麻醉中补充氧气可以阻断传统质子疗法中的FLASH效应和抗瘤免疫力
Lorea Iturri1,2, Annaïg Bertho1,2, Charlotte Lamirault3
1Institut Curie, Université PSL, CNRS UMR3347, Inserm U1021, Signalisation Radiobiologie et Cancer, Orsay, France.
Communications medicine
|December 15, 2023
概括
在麻醉期间补充氧气会恶化大脑损伤,并在质子疗法中降低抗瘤免疫力. 优化麻醉对于保护正常组织和提高癌症治疗疗效至关重要.
科学领域:
- 神经瘤学神经瘤学
- 辐射瘤学 辐射瘤学
- 免疫学 免疫学 免疫学
背景情况:
- 辐射诱导的神经认知功能障碍是儿童脑瘤幸存者的重要关注点.
- 质子疗法通常用于儿科患者,需要用补充氧气进行麻醉.
- 这项研究调查了在麻醉期间补充氧气对正常组织毒性和抗瘤免疫力的影响.
研究的目的:
- 为了评估在麻醉期间补充氧气对质子疗法后正常大脑组织毒性的影响.
- 评估补充氧气对传统和FLASH质子疗法后抗瘤免疫反应的影响.
主要方法:
- 费舍尔344只大鼠接受了常规或FLASH质子疗法 (15Gy或25Gy) 的头骨辐射.
- 使用组织学,细胞计和行为分析评估了正常组织毒性.
- 瘤透白细胞通过流细胞计量在携带质母细胞瘤的老鼠中得到量化.
主要成果:
- 补充氧气在质子疗法后对正常大脑组织的功能和解剖评估产生了不利影响.
- 在麻醉期间补充氧气对抗瘤免疫反应产生了不利影响,抑制了免疫细胞透到瘤中.
结论:
- 这些发现突显了补充氧气对正常脑组织和抗瘤免疫力的有害影响.
- 在放射治疗中优化麻醉方案是必要的,以保护正常组织并改善瘤控制,特别是免疫治疗.
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