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手术管理和BIA-ALCL的长期结果:一个多学科的方法

Joshua Vorstenbosch¹, Paola Ghione², George Plitas³

¹Division of Plastic Surgery, McGill University, Montreal, QC, Canada.

Annals of surgical oncology

|December 15, 2023

概括

完全手术切除乳房植入物和周围的囊有效地治疗与乳房植入物相关的可塑性大细胞淋巴瘤 (BIA-ALCL),导致早期疾病的高生存率.

科学领域:

在瘤学瘤学.
整形外科整形外科整形外科
医疗器械安全医疗器械安全

背景情况:

乳房植入物相关的形大细胞淋巴瘤 (BIA-ALCL) 是一种与纹理乳房植入物相关的罕见恶性瘤.
治疗方法和结果在各个机构中各不相同.
这项研究侧重于单一机构的队列,以标准化手术和治疗方案.

研究的目的:

为了评估BIA-ALCL患者在一个中心接受外科切除治疗的结果.
评估双边植入物切除和完整囊切除术的疗效.
分析与疾病阶段相关的无进展和整体生存率.

主要方法:

从2011年到2020年,在纪念斯隆凯特林癌症中心 (MSKCC) 治疗的18例BIA-ALCL病例的回顾性分析.
纳入标准:为BIA-ALCL而接受植入物切除和囊切除的乳腺植入的妇女.
收集了关于患者人口统计,植入病史,临床表现,阶段和随访结果的数据.

主要成果:

诊断时的中位数年龄为57岁,植入植入物的中位数暴露时间为11年.
所有确定的植入物都具有Biocell宏观结构;89%用于乳房重建.
78%的患者呈现出出血,17%的患者呈现出质量;83%的患者被诊断为1期BIA-ALCL.
在43.4个月的中位随访期间,没有观察到BIA-ALCL的复发或死亡.

结论:

适当的手术治疗,包括双边植入物切除和完整的囊切除,对于BIA-ALCL的管理至关重要.
早期诊断和治疗有限阶段的BIA-ALCL与良好的无进展和整体存活率有关.
这一单一机构的经验支持了BIA-ALCL的积极的外科治疗.

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