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Updated: Jul 8, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Published on: June 7, 2019

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由SOX10缺乏引起的LAMB3上调决定了MAPKi抗性黑色素瘤的侵袭性

Shujun Han1, Mo Zhang1, Xiaoyan Qu1

  • 1Frontier Institute of Science and Technology, and Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.

Oncogene
|December 15, 2023
PubMed
概括

抗MAPK抑制剂 (MAPKi) 的黑色素瘤细胞变得更具侵入性. 这项研究揭示了一个SOX10-低/TGF-β/LAMB3通路驱动黑色素瘤细胞迁移和入侵,表明LAMB3作为治疗点.

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