在患有肥胖和肠道失调症的患者中肝脏细菌殖民
Lucia Paiano1,2, Manuela Mastronardi3,4, Giuseppina Campisciano5
1Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy.
Obesity surgery
|December 15, 2023
概括
这项研究在减肥患者的肝活检中发现了细菌基因组,与肠道微生物群中减少的Roseburia intestinalis有关. 这表明在肥胖中存在潜在的肠道屏障功能障碍.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 肥胖问题研究研究
背景情况:
- 肠道微生物群,肝炎和肥胖之间的联系是一个日益增长的研究领域.
- 肠道功能失调可能在与肥胖相关的肝脏疾病中起作用.
研究的目的:
- 研究肥胖患者肠道微生物群失生症与肝脏活检中细菌基因组的存在之间的关系.
- 在肥胖的背景下,探索特定肠道细菌和肝脏殖民之间的潜在联系.
主要方法:
- 一项前性研究,涉及23名接受减肥手术的患者.
- 收集和分析人体测量,代谢,并发病,便和肝脏活检数据.
- 使用Ion Torrent下一代测序对V3-16SrRNA区域进行测序.
主要成果:
- 在23名患者中有8名 (34.7%) 的肝活检中检测到细菌基因组.
- 在共同殖民的样本中发现了Prevotella,Bacteroides,Streptococcus和Dalister.
- 在肝脏细菌定居的患者的便样本中观察到Roseburia intestinalis的统计学显著减少 (1%对3%,p=0.0339).
结论:
- 这是第一个报告细菌基因组的研究,而不仅仅是与微生物相关的分子模式,在腹患者的肝脏活检中.
- 在肠道中减少的Roseburia intestinalis可能与增加的肠道和血管透性有关,可能导致细菌转移到肝脏.
- 研究结果表明,肠道失调,肝脏中的细菌存在和与肥胖有关的并发症之间存在联系.
相关概念视频
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