周围免疫功能和阿尔茨海默病:一个活生生的系统性审查和批判性评估
Chihua Li1,2,3, Rebecca C Stebbins4, Grace A Noppert5
1Social Environment and Health Program, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. chihuali@umich.edu.
Molecular psychiatry
|December 15, 2023
概括
周围免疫功能与阿尔茨海默病 (AD) 有关. 准免疫系统失衡可能是对抗阿尔茨海默病的新方法,尽管需要更多高质量的研究.
科学领域:
- 神经免疫学 神经免疫学
- 生物标志物发现发现
背景情况:
- 越来越多的证据将外周免疫功能与人类的阿尔茨海默病 (AD) 联系起来.
- 系统性审查对于综合当前研究和识别知识差距至关重要.
研究的目的:
- 系统地审查和描述对外围免疫生物标志物和AD的人类研究.
- 评估现有研究的质量,并为未来的研究提供建议.
主要方法:
- 在PubMed,PsycINFO和Web of Science数据库中进行全面的文献搜索.
- 分析了187个外围免疫生物标志物和AD之间的统计关联.
- 使用修改后的纽卡斯尔-太华尺度进行质量评估.
主要成果:
- 包括286项研究,主要是横截面和基于医院的研究.
- 对IL-6,IL-1β,IFN-γ,ACT,IL-18和IL-12发现了与AD的积极关联.
- 只有7.7%的研究被评为高质量.
结论:
- 关于周围免疫和AD的研究在方法上是多样化和有限的.
- 需要进行长度,以人口为基础的研究,以澄清外周免疫功能在AD中的作用.
- 针对外周免疫失调可能是AD的潜在治疗策略.
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