神经EGFL-like 1,一个与骨突合结合相关的骨质突合生成分子,与神经发育病理有着惊人的关联
Chenshuang Li1, Zhong Zheng2, Pin Ha2,3
1Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cell & bioscience
|December 16, 2023
概括
在小鼠中,神经EGFL-like-1 (Nell-1) 缺乏导致了类似自闭症谱系障碍的行为,被Risperidone纠正. 这项研究证实了Nell-1的存在.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 发展生物学 发展生物学
背景情况:
- 面综合征通常涉及骨和神经系统的异常,造成重大负担.
- 神经EGFL-like-1 (Nell-1) 已知在面组织中具有骨质性特征.
- 新出现的证据表明,Nell-1也可能影响中枢神经系统功能.
研究的目的:
- 研究Nell-1在神经行为发育和功能中的作用.
- 为了确定Nell-1哈普洛缺陷是否导致中枢神经系统异常.
- 探索Nell-1神经发育功能背后的分子机制.
主要方法:
- 对Nell-1-haploinsufficient (Nell-1+/6R) 的小鼠和野生类型的 littermates 的行为分析.
- 评估重复性,社交性,与焦虑相关的,运动,感觉,运动协调和学习行为.
- 海马体转录形状分析和替代拼接分析.
主要成果:
- 尼尔-1+/6R小鼠表现出类似于自闭症谱系障碍的核心缺陷.
- 这些行为缺陷通过Risperidone治疗得到改善.
- 转录组分析显示,在Nell-1+/6R小鼠海马中,有269个差异表达的基因和改变的拼接.
结论:
- 尼尔-1在调节神经发育和功能方面发挥着至关重要的作用.
- 尼尔-1 缺乏导致自闭症谱系障碍类似的表型.
- 这项研究揭示了一个新的骨脑交叉声网络,为面患者治疗提供了洞察力.
更多相关视频
相关概念视频
Neurulation
42.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.0K
Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Enzyme-linked Receptors
78.5K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
78.5K
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
Immunoglobulin-like Cell Adhesion Molecules
3.3K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.3K


