基于多变量调整后勤回归的二二与代谢综合征的关联:美国全国人口研究2003-2016年
Jing Cai1, Zhichao Yang1, Sen Zhao1
1Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou, 310053, P.R. China.
Environmental health : a global access science source
|December 16, 2023
概括
尿液中较高的二甲 (p-DCB) 含量,特别是2,5-二甲 (2,5-DCP),与代谢综合征 (MetS) 的患病率增加有关. 这一发现表明与p-DCB暴露相关的潜在环境健康风险.
科学领域:
- 环境健康 环境健康
- 代谢障碍 代谢障碍 代谢障碍
- 毒理学 毒理学 毒理学
背景情况:
- 关于对二二 (p-DCB) 暴露和氧化应激,公众存在担忧.
- 暴露在p-DCB和代谢综合征 (MetS) 之间的关联仍然不清楚.
- 这项研究调查了美国人口中p-DCB暴露与MetS风险之间的潜在联系.
研究的目的:
- 检查p-DCB暴露和MetS流行之间的关联.
- 为了确定较高的p-DCB暴露是否与发展MetS的风险增加有关.
主要方法:
- 从国家健康和营养检查调查 (2003-2016) 中对10,428名参与者的分析.
- 根据NCEP/ATPIII标准诊断的MetS病例.
- 逻辑回归,量子量和 (WQS) 回归和量子量g计算 (qgcomp) 用于评估关联.
主要成果:
- 在尿中2,5-二二醇 (2,5-DCP) 水平和MetS患病率之间发现了显著的积极关联.
- 增加的2,5-DCP与更高的腹部肥胖率,高静脉血压,更大的腰围和更高的葡萄糖血红蛋白有关.
- 在2,5-DCP和高密度胆固醇水平之间观察到显著的反相关性.
结论:
- 尿中的p-DCB度升高,特别是2,5-DCP,与更高的MetS.流行率有关.
- 这些发现表明潜在的环境健康问题需要谨慎解释.
- 需要进一步的研究来验证这些关联,并了解潜在的机制.
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