衰老,癌症和免疫的相互联系:现实世界的回顾性研究结果
Xiaomin Fu1, Peng Qin2, Fanghui Li1
1Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450003, China.
Immunity & ageing : I & A
|December 16, 2023
概括
癌症患者表现出免疫细胞减少和PD-1表达升高,表明免疫系统发生了变化. 这些发现提供了关于衰老,癌症和免疫力之间的相互作用的见解,可能有助于治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 老年学是一门学科.
背景情况:
- 免疫功能下降与癌症有关,但对周围血液免疫变化的临床研究在衰老和癌症是有限的.
- 关于癌症患者免疫系统变化的真实数据很少,特别是关于衰老的数据.
研究的目的:
- 分析癌症患者的周围血液免疫变化,与健康个体相比.
- 为了研究免疫细胞计数,PD-1表达,衰老和癌症阶段之间的关系.
- 建立周围血液中PD-1阳性细胞的参考范围,并探索它们作为预测生物标志物的潜力.
主要方法:
- 追溯病例控制研究涉及1375名癌症患者和275名年龄/性别匹配的健康对照.
- 流细胞计用于评估免疫细胞群和PD-1表达.
- 使用SPSS 17.0和GraphPad Prism 9软件进行的统计分析.
主要成果:
- 与对照人群相比,癌症患者的CD3+ T细胞,CD4+ Th细胞,CD8+ CTL细胞,B细胞和NK细胞的数量显著降低,PD-1阳性细胞减少 (P < 0.0001).
- 免疫细胞数量减少与年龄和癌症阶段相相关.
- PD-1阳性细胞百分比因癌症类型而异,随年龄和阶段而增加,在不同癌症诊断中显示出不同的模式.
结论:
- 该研究提供了外周血液中PD-1阳性细胞的参考范围,并证实了癌症患者的免疫细胞减少.
- 这些发现增强了对衰老,癌症和免疫之间的复杂相互作用的理解.
- 循环的PD-1阳性细胞分布反映了瘤突变负担,表明它有可能作为免疫检查点抑制剂治疗的预测生物标志物.
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