三甘油糖指数轨迹与高血压有关:一个回顾性的纵向队列研究
Fengling Xin1, Shuyou He2, Yu Zhou1
1School of Public Health, Dalian Medical University, No.9, West Section of Lushunkou Road, Lushunkou District, Dalian, Liaoning, 116000, China.
高甘油三糖 (TyG) 指数轨迹与高血压风险有关. 早期识别不断增加的TyG指数模式可能有助于预防未来的高血压.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 三甘油糖 (TyG) 指数轨迹与心血管疾病有关.
- 泰格指数模式与高血压风险之间的关联仍未得到充分研究.
研究的目的:
- 在一般人群中,在12年内识别出明显的甘油三糖 (TyG) 指数轨迹.
- 分析这些TyG指数轨迹与高血压发病率之间的关联.
主要方法:
- 基于小组的轨迹建模被用于确定15056名成年人的TyG指数模式.
- 考克斯回归分析评估了TyG指数轨迹与高血压发病率之间的关联.
- 计算的TyG指数为 ln ((禁食时的TG × FPG/2).
主要成果:
- 确定了三种不同的TyG指数轨迹:"低增长"",中等增长"和"高稳定".
- 无论是"中度增加"还是"高度稳定"的轨迹都与高血压风险显著增加有关,即使经过多种风险因素的调整.
- 较高的TyG指数轨迹与高血压风险之间的关联在女性中比男性更为明显.
结论:
- 基线提升的TyG指数和长期TyG指数轨迹都与高血压风险增加有关.
- 早期识别 TyG 指数轨迹不断增加的个体,可以为高血压预防策略提供信息.
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