在精神分裂症的收费类受体mRNA水平:与补充因子的关联和环状回膜皮层稀释
Thomas W Weickert1,2,3, Ellen Ji4,5, Cherrie Galletly6,7,8
1Neuroscience Research Australia, Schizophrenia Research Institute, Randwick, NSW 2031, Australia.
Schizophrenia bulletin
|December 16, 2023
概括
精神分裂症涉及天生的免疫系统激活,与托尔类受体 (TLRs) 和补充系统失调. 在精神分裂症患者中,TLR4和TLR8的升高和TLR3的降低与免疫标记物以及 cingulate皮质厚度的降低相关.
科学领域:
- 神经免疫学 神经免疫学
- 精神疾病 精神疾病
- 这是天生的免疫力.
背景情况:
- 精神分裂症 (SZ) 与先天性免疫系统激活有关.
- 收费类受体 (TLR) 和补体系统是SZ.中涉及的先天免疫的关键组成部分.
- TLRs识别了各种与病原体相关的分子模式,包括细菌 (TLR1,TLR4) 和病毒 (TLR3,TLR8) 分子.
研究的目的:
- 在精神分裂症患者 (SZ) 和健康对照者 (HC) 之间比较TLR1,TLR3,TLR4和TLR8的外围mRNA水平.
- 调查SZ中TLRs,免疫激活 (补充表达) 和大脑结构 (状环皮层厚度) 之间的关系.
- 探索细菌与病毒免疫影响在精神分裂症的潜在差异.
主要方法:
- 从86名SZ和77名HC个体收集了周围血液白细胞.
- 量化了TLR1,TLR3,TLR4,TLR8和补充受体的mRNA水平.
- 在一小部分参与者身上进行了结构性MRI扫描,以测量皮质厚度.
主要成果:
- 与HC相比,SZ患者的TLR4和TLR8mRNA水平显著更高,TLR3mRNA水平较低.
- 在SZ和HC组中,TLR和补充因子表达显著相关.
- 在SZ个体中观察到较高的TLRmRNA水平,特别是TLR4和TLR8,具有较高的补充表达.
- 在 SZ 和 HC 组中,发现了TLR mRNA 水平和环状回膜皮质厚度之间的反向关联.
结论:
- 这些发现支持托尔类受体和补充系统在精神分裂症中观察到的先天免疫激活中的协调作用.
- 观察到的TLR表达模式表明,在精神分裂症中,潜在的细菌比病毒免疫系统的影响更大.
- 特定的TLRs与大脑皮层厚度的减少有关,例如带状回环,突出显示了神经生物学联系.
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